| Oligos for Click Chemistry |
forms rigid binding using Huisgen[3+2]cyclization. This reaction is scarcely influenced by environment of reaction system and conditions,
and proceeds even in aqueous·biocompatible conditions.
* Click chemistry is coined terms against Huisgen[3+2]cyclization(additional cyclization of alkyne azide)
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Outlined Chart of Reaction
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| We have lined up DNA Oligos which can be used for reaction system of Click Chemistry. |
| * Please inquire for prices and delivery time. |
 Azido (-N3) modified DNA Oligos
It can form binding with alkyne structure. |
| < 5'Azido structural formula > | < 3' Azidostructural formula > |
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Alkyne (-C≡CH) modified DNA Oligos
It can form binding with azide structure. |
| < 5'Alkyne structural formula > | < 3'Alkyne structural formula > |
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| It is also possible to undergo internal modification introducing azide in the base part of the sequence or in alkyne. |
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| Reference Literature |
| Cyclization of Oligonucleotides |
| Cyclization of Oligonucleotides J.Lietard,A.Meyer,J.J.Vasseur,and F.Morvan, Journal of Organic Chemistry,2008,73,191-200 |
| Conjugation of peptide-DNA |
| Conjugation of peptide-DNA K.Gogoi,M.V.Mane,S.S Kunte, and V.A.Kumar,Nucleic Acids Res.,2007,35,e139 |
| Immobilization of Oligonucleotides |
| Immobilization of Oligonucleotides M.V.Kvach, et al.,Nucleosides Nucleotides & Nucleic Acids,2007,26,809-813.D.I.Rozkiewicz, et al., Chembiochem 2007, 8, 1997-2002. |
| Fluorescent Labeling |
| Fluorescent Labeling Y.H.Zhang, et al., Tetrahedron, 2007, 63, 6813-6621. |
| Assembly of DNA on Gold nanoparticles |
| Assembly of DNA on Gold nanoparticles M.Fischler, et al.,Chem Commun(Camb)2008,169-71 |
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