| March | 1994 | Established R&D Company( Bio Venture originating from Tohoku University). |
| | 1st Director of Research Lab. Takuji Takeuchi ( Professor Emeritus of Tohoku University). |
| April | 1994 | Registered the laboratory as Sendai Clinical Laboratory( chromosome · genetic testing). |
| | Started subcontracting of chromosome and genetic testing. |
| April | 1995 | Started DNA · RNA synthesis in the filed of organic synthesis. |
| December | 1995 | Licensed from Roche Diagnostics GmbH for manufacturing and marketing of Digoxigenin (Dig) label. |
| January | 1996 | 2nd Director of Laboratory, Kan-ichi Nakagawara. |
| Research History |
| April | 1996 | Started Subcontracting Service for FISH Chromosome mapping. |
| April | 1998 | Development of Salt Free Oligo® DNA. |
| August | 1999 | Development of FISH probe by commissioned research fund. |
| | Started implementing Multi-color FISH for all kinds of blood diseases. |
| September | 1999 | Licensed by Roche Diagnostics GmbH for manufacturing and marketing of LightCycler®Red label. |
| | Entered into an alliance with Roche Disgnostics GmbH in order to form platform for LightCycler® and MagNA Pure and launched application laboratory for LightCycler®. |
| October | 1999 | Started services for animal chromosome analysis. |
| | Development of metaphase division inhibitor(NSA prototype). |
| June | 2000 | Reading Project of sea squirt genome, cooperation for sea squirt chromosome analysis. |
| September | 2002 | Development of chromosome analysis software( compatible to Windows 2000). |
| October | 2002 | Started sales of primer probe set for LightCycler® in Japan. |
| May | 2003 | Registered trade mark of Salt Free Oligo®. |
| March | 2004 | Started chromosome analysis service for knockout mouse ES cells. |
| May | 2004 | Concluded Cooperative Agreement with US Air Force Research Laboratory. |
| June | 2004 | Constructed general control system of chromosome. |
| January | 2005 | Started synthesis service for siRNA. |
| March | 2005 | Licensed PCR Technology from F. Hoffmann-La Roche Ltd. |
| | Licensed RT and RT-PCR Technology from F. Hoffmann-La Roche Ltd. |
| | Licensed 5' Nuclease Technology from F. Hoffmann-La Roche Ltd. |
| | Licensed Intercalation Technology from F. Hoffmann-La Roche Ltd. |
| April | 2005 | Started quantitative analysis of genetic expression by LightCycler®. |
| | Started subcontracting of genotyping analysis by LightCycler®. |
| January | 2006 | Licensed from Roche Diagnostics GmbH for manufacturing and marketing of primer probe set for LightCycler® in Japan, Korea, China and Malaysia. |
| June | 2006 | Licensed from Biosearch Technologies, Inc. for manufacturing and marketing of Black Hole Quencher (BHQ). |
| | Licensed from GE Healthcare Biosciences Corp. for manufacturing and marketing of CyDye labeled products. |
| September | 2006 | Development of metaphase division inhibitor (NSA). |
| January | 2007 | oncluded subcontracting agreement of Nucleic Acid purification for Nimblegen micro array with Roche Diagnostics GmbH. |
| July | 2007 | Licensed from Carnegie Institution for manufacturing and marketing of RNA synthesized products for RNAi. |
| June | 2008 | Licensed from Hoffmann-La Roche Ltd. for manufacturing and marketing of IVD products. |
| November | 2008 | JMCoE related IVD products, started sales of CMV determination reagent. |
| January | 2009 | JMCoE related IVD products, started sales of EBV determination reagent. |
| February | 2009 | Started chromosome analysis service for iPS cells of human, mouse and rat. |
| September | 2009 | Registered Poisonous Material Importer (Registered Number: 00006). |
| | Registered as Clinical Research Laboratory in Sendai (added microbiological testing). |
| | Started subcontracting of HPV genetic testing. |
| November | 2009 | Started subcontracting of genetic testing of new-type influenza. |
| February | 2010 | Started support business from Tohoku Economics Federation. |
| July | 2010 | Construction of genetic testing control system. |
| September | 2010 | Patent applied for Primer Stabilizer. |
| | Patent Application for Total RNA Stabilizer. |
| | Patent Application for ssRNA Stabilizer. |
NGRL is a venture company originating from Tohoku University. It was founded in March 1994 as a R&D research laboratory looking into true nature of life phenomenon from gene research. Since our foundation, we have been putting our efforts in performing services for our customers such as chromosome · FISH testing, DNA · RNA and siRNA synthesis and quantitative analysis of genes, and as the result of those experiences, we have come so far as to line up gene research products. It was found that accumulation efficiency of abnormal cells would be enhanced if our recent development of metaphase division inhibitor (NSA-1, patent pending) was used. Based on this technology as a platform, we are aiming at a leader in safety testing of chromosome such as iPS cells · ES cells · strained cells. In the field of organic synthesis such as DNA · RNA , we have been researching for many years how to suppress dissolution of mRNA. In August 2010, we succeeded to develop a reagent to enable storage of RNA for longer period at 4℃. It is expected that this reagent is capable of storing RNA in room temperature( patent pending). This RNA storing reagent as a platform, we are considering various applications such as ssRNA Standard to be used for quantification of genes as well as total RNA for precision control of real-time PCR. Thus, based on many of your support, results of development have become visible now. We sincerely wish your continued support to us and also hope your utilization of our technologies.
